Insights in Neurosurgery

Comparative Effect of Different Group of Oximes on the Reactivity of Inhibited Acetylcholinesterase

The use of pesticides and insecticides has increased in agricultural field and household etc for pest control, pest management and to prevent diseases caused by insects respectively over a period. Insecticides are also a category of pesticides. Some of the most abundantly used pesticides contain organophosphate compounds as basic ingredient. Organophosphate compounds are ester, amide and thiol derivatives of phosphoric acid. Such compounds are highly toxic and their accumulation in the human body can cause neuro-poisoning. They deactivate the human acetylcholinesterase (AChE) and thus stop the acetylcholine neurotransmission. Although the process is not permanent, it depends upon how much time the interaction between organophosphate compound and AChE has taken before the aging and denaturation of the enzyme starts. Before aging of the enzyme, a group of compounds known as Oximes belonging to the family of amines can be used to reactivate the human acetylcholinesterase.

Author(s):

Muhammad Sibte Hasan Mahmood

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